| TORNEO DE INICIALIZACION 2022 | ||||
| 1ª Fase | ||||
| 1º Fecha | ||||
| 20-ene-2022 | Rionegro | Aguilas Doradas | 1 | Rodriguez |
| Bucaramanga | 1 | Caballero | ||
| 20-ene-2022 | Palmira | Cali | 1 | Batalla |
| Envigado | 0 | |||
| 21-ene-2022 | Bogota | Santa Fe | 1 | De la Rosa |
| La Equidad | 1 | Lima | ||
| 21-ene-2022 | Pasto | Pasto | 0 | |
| Millonarios | 1 | Herazo | ||
| 22-ene-2022 | Tulua | Cortulua | 1 | Ruiz (P) |
| Nacional | 1 | Duque | ||
| 22-ene-2022 | Manizales | Once Caldas | 1 | Carreazo |
| Union Magdalena | 1 | Sanchez | ||
| 22-ene-2022 | Barranquilla | Junior | 3 | Gonzalez (2), Borja (P) |
| Patriotas | 1 | Bolaños | ||
| 23-ene-2022 | Medellin | Medellin | 1 | Pardo |
| Tolima | 0 | |||
| 23-ene-2022 | Monteria | Jaguares de Cordoba | 2 | Urrego, Renteria |
| Cali | 1 | Velasco (P) | ||
| 23-ene-2022 | Barrancabermeja | Alianza Petrolera | 2 | Manjarres, Londoño |
| Pereira | 1 | Castro | ||
| 2º Fecha | ||||
| 25-ene-2022 | Envigado | Envigado | 1 | Londoño |
| Pasto | 0 | |||
| 25-ene-2022 | Bogota | Santa Fe | 3 | Morelo (2, 1P), Pedroza |
| Aguilas Doradas | 0 | |||
| 25-ene-2022 | Bucaramanga | Bucaramanga | 0 | |
| Millonarios | 0 | |||
| 26-ene-2022 | Bogota | La Equidad | 1 | Sabbag |
| Once Caldas | 2 | Garcia, Valdes | ||
| 26-ene-2022 | Monteria | Jaguares de Cordoba | 2 | Castaño (2) |
| Cortulua | 1 | Castillo | ||
| 26-ene-2022 | Palmira | Cali | 0 | |
| Tolima | 1 | Ibarguen | ||
| 26-ene-2022 | Medellin | Nacional | 3 | Moreno (A), Mantilla, Pabon |
| Junior | 1 | Uribe | ||
| 27-ene-2022 | Santa Marta | Union Magdalena | 0 | |
| Alianza Petrolera | 0 | |||
| 27-ene-2022 | Tunja | Patriotas | 2 | Moreno (A), Lopez |
| Medellin | 0 | |||
| 27-ene-2022 | Pereira | Pereira | 1 | Ramirez (P) |
| America | 1 | Sierra | ||
| 3º Fecha | ||||
| 29-ene-2022 | Tulua | Cortulua | 1 | Ruiz |
| Santa Fe | 1 | Mosquera | ||
| 29-ene-2022 | Rionegro | Aguilas Doradas | 1 | Blanco |
| Once Caldas | 1 | Quiñonez | ||
| 29-ene-2022 | Barranquilla | Junior | 1 | Fuentes (P) |
| La Equidad | 0 | |||
| 29-ene-2022 | Bogota | Millonarios | 0 | |
| Nacional | 2 | Guzman, Palacios | ||
| 30-ene-2022 | Tunja | Patriotas | 2 | Barrios, Lopez |
| Pereira | 3 | Castro (3) | ||
| 30-ene-2022 | Medellin | Medellin | 2 | Pons (2) |
| Cali | 0 | |||
| 30-ene-2022 | Cali | America | 3 | Sierra (2), Angulo |
| Bucaramanga | 0 | |||
| 30-ene-2022 | Barrancabermeja | Alianza Petrolera | 2 | Arango, Fernandez |
| Envigado | 2 | Hernandez (P), Londoño (P) | ||
| 31-ene-2022 | Pasto | Pasto | 1 | Escalante |
| Jaguares de Cordoba | 1 | Renteria (P) | ||
| 31-ene-2022 | Ibague | Tolima | 2 | Rangel (P), Orozco |
| Union Magdalena | 1 | Sanchez | ||
| 4º Fecha | ||||
| 2-feb-2022 | Bucaramanga | Bucaramanga | 2 | M. Acosta, Marcelin |
| Alianza Petrolera | 1 | S. Acosta | ||
| 2-feb-2022 | Envigado | Envigado | 0 | |
| Millonarios | 0 | |||
| 2-feb-2022 | Palmira | Cali | 1 | Leyton |
| Pereira | 0 | |||
| 2-feb-2022 | Bogota | Santa Fe | 2 | De la Rosa, Ortiz |
| Junior | 1 | Hinestroza | ||
| 3-feb-2022 | Bogota | La Equidad | 0 | |
| Aguilas Doradas | 1 | Perez | ||
| 3-feb-2022 | Santa Marta | Union Magdalena | 0 | |
| Pasto | 0 | |||
| 3-feb-2022 | Monteria | Jaguares de Cordoba | 3 | Viveros, Renteria, Urrego |
| Patriotas | 1 | Urrego (A) | ||
| 3-feb-2022 | Medellin | Nacional | 0 | |
| Tolima | 1 | Ramirez | ||
| 4-feb-2022 | Tulua | Cortulua | 2 | Valencia, Ruiz |
| America | 0 | |||
| 4-feb-2022 | Manizales | Once Caldas | 2 | Carreazo, Garcia |
| Medellin | 1 | Pons | ||
| 5º Fecha | ||||
| 5-feb-2022 | Envigado | Envigado | 1 | Hernandez |
| Cali | 0 | |||
| 6-feb-2022 | Tunja | Patriotas | 0 | |
| La Equidad | 1 | Estupiñan | ||
| 6-feb-2022 | Ibague | Tolima | 2 | Ramirez (2) |
| Bucaramanga | 1 | Moreno | ||
| 6-feb-2022 | Bogota | Millonarios | 1 | Gomez (A) |
| Union Magdalena | 0 | |||
| 6-feb-2022 | Pasto | Pasto | 0 | |
| Nacional | 1 | Duque | ||
| 7-feb-2022 | Barrancabermeja | Alianza Petrolera | 2 | Saldaña, Fernandez |
| Jaguares de Cordoba | 0 | |||
| 7-feb-2022 | Barranquilla | Junior | 2 | Hinestroza, Borja |
| Aguilas Doradas | 1 | Marrugo (P) | ||
| 7-feb-2022 | Cali | America | 2 | Ramos (P), Malagon (A) |
| Santa Fe | 2 | Morelo, Mier | ||
| 8-feb-2022 | Medellin | Medellin | 3 | Hernandez, Cadavid (P), Pons |
| Cortulua | 1 | Ruiz (P) | ||
| 9-mar-2022 | Pereira | Pereira | 0 | |
| Once Caldas | 1 | Perez (P) | ||
| 6º Fecha | ||||
| 11-feb-2022 | Santa Marta | Union Magdalena | 2 | Vega, Gonzalez |
| Envigado | 1 | Rojas | ||
| 11-feb-2022 | Bucaramanga | Bucaramanga | 0 | |
| Pasto | 1 | Riascos | ||
| 11-feb-2022 | Medellin | Nacional | 0 | |
| Alianza Petrolera | 0 | |||
| 12-feb-2022 | Tulua | Cortulua | 1 | Ruiz |
| Patriotas | 0 | |||
| 12-feb-2022 | Bogota | La Equidad | 2 | Moreno, Lima (P) |
| Medellin | 1 | |||
| 12-feb-2022 | Manizales | Once Caldas | 1 | Cordoba |
| Junior | 0 | |||
| 12-feb-2022 | Rionegro | Aguilas Doradas | 2 | Artunduaga, Perez (P) |
| America | 0 | |||
| 13-feb-2022 | Bogota | Santa Fe | 1 | Mier (P) |
| Pereira | 2 | Leon, Valencia | ||
| 13-feb-2022 | Palmira | Cali | 0 | |
| Millonarios | 2 | Herazo (P), Sosa | ||
| 13-feb-2022 | Monteria | Jaguares de Cordoba | 0 | |
| Tolima | 2 | Miranda, Lucumi | ||
| 7º Fecha | ||||
| 15-feb-2022 | Santa Marta | Union Magdalena | 0 | |
| Bucaramanga | 1 | Perez | ||
| 15-feb-2022 | Envigado | Envigado | 1 | Quintana (A) |
| Nacional | 2 | Moreno, Duque (P) | ||
| 16-feb-2022 | Pereira | Pereira | 2 | Leon (2) |
| Jaguares de Cordoba | 1 | Viveros | ||
| 16-feb-2022 | Ibague | Tolima | 3 | Rios, Lucumi, Rangel |
| Santa Fe | 0 | |||
| 16-feb-2022 | Bogota | Millonarios | 2 | Ruiz, Valencia |
| Aguilas Doradas | 0 | |||
| 16-feb-2022 | Medellin | Medellin | 2 | Pons (2) |
| Junior | 0 | |||
| 17-feb-2022 | Tunja | Patriotas | 0 | |
| Once Caldas | 0 | |||
| 17-feb-2022 | Barrancabermeja | Alianza Petrolera | 0 | |
| Cortulua | 0 | |||
| 17-feb-2022 | Pasto | Pasto | 2 | Riascos, Escalante |
| Cali | 0 | |||
| 17-feb-2022 | Cali | America | 1 | Sanchez |
| La Equidad | 1 | Camacho | ||
| 8º Fecha | ||||
| 19-feb-2022 | Bogota | Santa Fe | 1 | Sanchez |
| Medellin | 0 | |||
| 19-feb-2022 | Monteria | Jaguares de Cordoba | 1 | Renteria |
| Millonarios | 2 | Guerra, Valencia | ||
| 19-feb-2022 | Medellin | Nacional | 1 | Blanco |
| Union Magdalena | 0 | |||
| 20-feb-2022 | Tulua | Cortulua | 2 | Castillo, Ruiz |
| Pereira | 1 | Lugo | ||
| 20-feb-2022 | Palmira | Cali | 1 | Leyton (P) |
| Alianza Petrolera | 1 | Fernandez | ||
| 20-feb-2022 | Barranquilla | Junior | 1 | Gonzalez |
| America | 0 | |||
| 20-feb-2022 | Bogota | La Equidad | 0 | |
| Tolima | 0 | |||
| 21-feb-2022 | Bucaramanga | Bucaramanga | 1 | Dayro Moreno |
| Envigado | 2 | Hernandez, Diego Moreno | ||
| 22-feb-2022 | Rionegro | Aguilas Doradas | 1 | Salazar |
| Patriotas | 0 | |||
| 22-feb-2022 | Manizales | Once Caldas | 3 | Carreazo, Garcia (2) |
| Pasto | 0 | |||
| 9º Fecha | ||||
| 26-feb-2022 | Envigado | Envigado | 3 | Barragan (2), Zapata |
| Jaguares de Cordoba | 1 | Renteria (P) | ||
| 26-feb-2022 | Pereira | Pereira | 2 | Castro (2) |
| La Equidad | 3 | Camacho, Sabbag, Estupiñan | ||
| 26-feb-2022 | Ibague | Tolima | 0 | |
| Junior | 2 | Borja (P), Albornoz | ||
| 26-feb-2022 | Bogota | Millonarios | 1 | Pereira |
| Cortulua | 0 | |||
| 27-feb-2022 | Santa Marta | Union Magdalena | 0 | |
| Cali | 2 | Vasquez, Luna | ||
| 27-feb-2022 | Bucaramanga | Bucaramanga | 3 | Teliz, Cardenas, Marcelin |
| Nacional | 1 | Andrade | ||
| 27-feb-2022 | Cali | America | 2 | Quintana (2) |
| Once Caldas | 0 | |||
| 28-feb-2022 | Tunja | Patriotas | 1 | Barrios (P) |
| Santa Fe | 1 | Malagon | ||
| 1-mar-2022 | Pasto | Pasto | 1 | Estacio |
| Alianza Petrolera | 1 | Acosta | ||
| 1-mar-2022 | Medellin | Medellin | 4 | Pardo, Pineda, Arregui, Pons |
| Aguilas Doradas | 0 | |||
| 10º Fecha | ||||
| 4-mar-2022 | Manizales | Once Caldas | 0 | |
| Pereira | 0 | |||
| 5-mar-2022 | Barranquilla | Junior | 3 | Gonzalez, Cetre, Borja (P) |
| Union Magdalena | 1 | Sanchez (P) | ||
| 5-mar-2022 | Palmira | Cali | 0 | |
| America | 1 | Ramos | ||
| 5-mar-2022 | Bogota | La Equidad | 1 | Sabbag (P) |
| Patriotas | 1 | Bolaños | ||
| 6-mar-2022 | Barrancabermeja | Alianza Petrolera | 2 | Fernandez, Angulo |
| Bucaramanga | 2 | Moreno (2) | ||
| 6-mar-2022 | Bogota | Santa Fe | 0 | |
| Millonarios | 3 | Vasquez, Herazo, Guerra | ||
| 6-mar-2022 | Medellin | Atletico Nacional | 2 | Cabal, Mantilla |
| Medellin | 0 | |||
| 7-mar-2022 | Tulua | Cortulua | 1 | Valencia |
| Tolima | 3 | Plata, Caicedo, Miranda | ||
| 8-mar-2022 | Rionegro | Aguilas Doradas | 1 | Jaramillo |
| Envigado | 1 | Barragan, Sinisterra | ||
| 8-mar-2022 | Monteria | Jaguares de Cordoba | 1 | Castellanos |
| Pasto | 0 | |||
| 11º Fecha | ||||
| 16-mar-2022 | Ibague | Tolima | 1 | Cataño (P) |
| Patriotas | 2 | Lopez, Danloux | ||
| 16-mar-2022 | Bucaramanga | Bucaramanga | 1 | Perez |
| Cali | 0 | |||
| 16-mar-2022 | Pasto | Pasto | 2 | Riascos (2) |
| Santa Fe | 4 | Morelo (P), Gomez, Gonzalez, Goez | ||
| 17-mar-2022 | Medellin | Nacional | 3 | Barrera, Urrego (A), Blanco |
| Jaguares de Cordoba | 1 | Renteria | ||
| 18-mar-2022 | Santa Marta | Union Magdalena | 0 | |
| Cortulua | 2 | Castillo, Ruiz | ||
| 18-mar-2022 | Bogota | Millonarios | 1 | Ruiz (P) |
| Once Caldas | 0 | |||
| 19-mar-2022 | Barrancabermeja | Alianza Petrolera | 2 | Chunga, Acuña |
| Aguilas Doradas | 1 | Marrugo (P) | ||
| 19-mar-2022 | Cali | America | 1 | Quiñones |
| Medellin | 3 | Arregui, Mosquera, Cambindo | ||
| 20-mar-2022 | Envigado | Envigado | 1 | Hernandez (P) |
| La Equidad | 1 | Camacho | ||
| 20-mar-2022 | Pereira | Pereira | 1 | Castro |
| Junior | 0 | |||
| 12º Fecha | ||||
| 21-mar-2022 | Montero | Jaguares de Cordoba | 2 | Castellanos, Scarpeta |
| Union Magdalena | 0 | |||
| 21-mar-2022 | Palmira | Cali | 3 | Gutierrez (P), Burdisso, Gonzalez |
| Nacional | 3 | Moreno, Pabon (2P) | ||
| 21-mar-2022 | Bogota | Santa Fe | 3 | Morelo (3) |
| Bucaramanga | 1 | Marcelin | ||
| 22-mar-2022 | Manizales | Once Caldas | 2 | Del Valle (2, 1P) |
| Tolima | 2 | Plata (2) | ||
| 22-mar-2022 | Tunja | Patriotas | 2 | Silva, Lopez |
| America | 1 | Ramos | ||
| 23-mar-2022 | Tulua | Cortulua | 1 | Colorado |
| Envigado | 1 | Asprilla | ||
| 23-feb-2022 | Bogota | La Equidad | 2 | Chaverra, Saldaña (A) |
| Alianza Petrolera | 1 | Colpa | ||
| 23-feb-2022 | Rionegro | Aguilas Doradas | 1 | Agudelo |
| Pereira | 0 | |||
| 23-feb-2022 | Medellin | Medellin | 1 | Cadavid (P) |
| Millonarios | 0 | |||
| 25-mar-2022 | Barranquilla | Junior | 1 | Valencia |
| Pasto | 1 | Arboleda | ||
| 13º Fecha | ||||
| 26-mar-2022 | Bucaramanga | Bucaramanga | 1 | Moreno (P) |
| Jaguares de Cordoba | 0 | |||
| 26-mar-2022 | Envigado | Envigado | 1 | Moreno |
| Once Caldas | 1 | Del Valle (P) | ||
| 26-mar-2022 | Santa Marta | Union Magdalena | 2 | Cantillo, Lloreda |
| Aguilas Doradas | 1 | Agudelo | ||
| 26-mar-2022 | Pereira | Pereira | 1 | Ramirez |
| Medellin | 1 | Pons | ||
| 27-mar-2022 | Palmira | Cali | 2 | Velasco, Gonzalez |
| Cortulua | 1 | Ruiz (P) | ||
| 27-mar-2022 | Barrancabermeja | Alianza Petrolera | 2 | Fernandez, Chunga |
| Patriotas | 1 | Perez | ||
| 27-mar-2022 | Ibague | Tolima | 1 | Rangel |
| America | 0 | |||
| 28-mar-2022 | Pasto | Pasto | 1 | Riascos |
| La Equidad | 1 | Camacho | ||
| 28-mar-2022 | Medellin | Nacional | 2 | Pabon, Andrade |
| Santa Fe | 1 | Ortiz | ||
| 30-mar-2022 | Bogota | Millonarios | 1 | Celis |
| Junior | 0 | |||
| 14º Fecha | ||||
| 1-abr-2022 | Bogota | La Equidad | 0 | |
| Cali | 0 | |||
| 2-abr-2022 | Medellin | Medellin | 2 | Pardo, Arregui |
| Envigado | 1 | Moreno | ||
| 2-abr-2022 | Pereira | Pereira | 0 | |
| Tolima | 2 | Miranda (2) | ||
| 2-abr-2022 | Tunja | Patriotas | 0 | |
| Nacional | 2 | Duque, Gomez | ||
| 2-abr-2022 | Barranquilla | Junior | 3 | Borja (2, 1P), Gonzalez |
| Alianza Petrolera | 1 | Londoño | ||
| 3-abr-2022 | Rionegro | Aguilas Doradas | 1 | Otalvaro |
| Jaguares de Cordoba | 1 | Rojas | ||
| 3-abr-2022 | Cali | America | 3 | Sierra (2), Mosquera |
| Millonarios | 2 | Ruiz (P), Vargas | ||
| 3-abr-2022 | Bogota | Santa Fe | 1 | Mena (A) |
| Union Magdalena | 0 | |||
| 4-abr-2022 | Tulua | Cortulua | 0 | |
| Pasto | 1 | Ospitaleche | ||
| 4-abr-2022 | Manizales | Once Caldas | 0 | |
| Bucaramanga | 1 | Moreno | ||
| 15º Fecha | ||||
| 8-abr-2022 | Bogota | Millonarios | 2 | Silva, Correa (A) |
| La Equidad | 1 | Sabbag | ||
| 9-abr-2022 | Ibague | Tolima | 3 | Rangel, Ibarguen (2) |
| Aguilas Doradas | 0 | |||
| 9-abr-2022 | Santa Marta | Union Magdalena | 0 | |
| Patriotas | 1 | Lopez | ||
| 9-abr-2022 | Palmira | Cali | 1 | Velasco |
| Junior | 1 | Borja | ||
| 10-abr-2022 | Envigado | Envigado | 1 | Guisao |
| Santa Fe | 0 | |||
| 10-abr-2022 | Medellin | Nacional | 2 | Banguero, Duque (P) |
| America | 0 | |||
| 10-abr-2022 | Barrancabermeja | Alianza Petrolera | 1 | Arango |
| Medellin | 1 | Cadavid | ||
| 11-abr-2022 | Monteria | Jaguares de Cordoba | 2 | Castellanos, Mancilla (A) |
| Once Caldas | 1 | Garcia | ||
| 11-abr-2022 | Pasto | Pasto | 2 | Riascos (P), Vergara |
| Pereira | 2 | Castro, Ramirez (P) | ||
| 12-abr-2022 | Bucaramanga | Bucaramanga | 3 | Cardenas, Millan (A), Blanco |
| Cortulua | 2 | Mercado, Millan | ||
| 16º Fecha | ||||
| 15-abr-2022 | Bogota | Santa Fe | 0 | |
| Alianza Petrolera | 1 | Gil | ||
| 16-abr-2022 | Manizales | Once Caldas | 1 | Perez (A) |
| Cortulua | 0 | |||
| 16-abr-2022 | Ibague | Tolima | 0 | |
| Pasto | 1 | Riascos | ||
| 16-abr-2022 | Bogota | La Equidad | 1 | Salazar |
| Jaguares de Cordoba | 0 | |||
| 16-abr-2022 | Barranquilla | Junior | 2 | Giraldo, Borja |
| Bucaramanga | 0 | |||
| 17-abr-2022 | Rionegro | Aguilas Doradas | 1 | Marrugo (P) |
| Nacional | 0 | |||
| 17-abr-2022 | Pereira | Pereira | 1 | Montoya |
| Millonarios | 0 | |||
| 17-abr-2022 | Cali | America | 1 | Ramos (P) |
| Cali | 1 | Gutierrez | ||
| 17-abr-2022 | Medellin | Medellin | 0 | |
| Union Magdalena | 0 | |||
| 18-abr-2022 | Tunja | Patriotas | 0 | |
| Envigado | 0 | |||
| 17º Fecha | ||||
| 23-abr-2022 | Bucaramanga | Bucaramanga | 2 | D. Moreno (2) |
| Medellin | 3 | V. Moreno, Pons, Cadavid (P) | ||
| 23-abr-2022 | Medellin | Nacional | 0 | |
| Once Caldas | 0 | |||
| 23-abr-2022 | Santa Marta | Union Magdalena | 0 | Mena |
| (*) | Junior | 3 | Serje | |
| 24-abr-2022 | Envigado | Envigado | 2 | Moreno (2) |
| Pereira | 1 | Piedrahita | ||
| 24-abr-2022 | Palmira | Cali | 0 | |
| Aguilas Doradas | 1 | Vasquez | ||
| 24-abr-2022 | Monteria | Jaguares de Cordoba | 1 | Viveros |
| America | 1 | Ramos | ||
| 24-abr-2022 | Bogota | Millonarios | 2 | Herazo, Meza (A) |
| Santa Fe | 1 | Moreno | ||
| 24-abr-2022 | Barrancabermeja | Alianza Petrolera | 0 | |
| Tolima | 2 | Caicedo, Orozco (P) | ||
| 25-abr-2022 | Tulua | Cortulua | 0 | |
| La Equidad | 2 | Chaverra, Lima (P) | ||
| 26-abr-2022 | Pasto | Pasto | 0 | |
| Patriotas | 0 | |||
| (*) Union Magdalena recibe sancion disciplinaria por disturbios de la hinchada y pierde los puntos. | ||||
| 18º Fecha | ||||
| 29-abr-2022 | Pereira | Pereira | 2 | Mosquera, Castro |
| Union Magdalena | 0 | |||
| 30-abr-2022 | Bogota | La Equidad | 1 | Motta |
| Bucaramanga | 1 | Diaz | ||
| 30-abr-2022 | Medellin | Medellin | 0 | |
| Nacional | 0 | |||
| 30-abr-2022 | Bogota | Santa Fe | 4 | Moreno, Gonzalez, Mier, Gomez |
| Jaguares de Cordoba | 0 | |||
| 30-abr-2022 | Ibague | Tolima | 3 | Ureña, Caicedo, Rangel |
| Cortulua | 2 | Ruiz (P), Valencia | ||
| 1-may-2022 | Manizales | Once Caldas | 0 | |
| Cali | 1 | Luna | ||
| 1-may-2022 | Tunja | Patriotas | 1 | Barrios |
| Millonarios | 2 | Gomez, Herazo | ||
| 1-may-2022 | Barrancabermeja | Junior | 4 | Angel, Uribe, Velasco, Valencia (P) |
| Envigado | 0 | |||
| 2-may-2022 | Rionegro | Aguilas Doradas | 1 | Vasquez |
| Pasto | 0 | |||
| 2-may-2022 | Cali | America | 0 | |
| Alianza Petrolera | 1 | Gil (P) | ||
| 19º Fecha | ||||
| 5-may-2022 | Santa Marta | Union Magdalena | 1 | Lloreda (P) |
| La Equidad | 1 | Chaverra | ||
| 6-may-2022 | Medellin | Nacional | 1 | Barrera |
| Pereira | 1 | Ramirez | ||
| 7-may-2022 | Bucaramanga | Bucaramanga | 1 | Moreno |
| Patriotas | 1 | De las Salas | ||
| 7-may-2022 | Palmira | Cali | 1 | Luna |
| Santa Fe | 1 | Morelo (P) | ||
| 7-may-2022 | Pasto | Pasto | 3 | Ayala, Estacio, Riascos (P) |
| America | 1 | Lemos (P) | ||
| 7-may-2022 | Monteria | Jaguares de Cordoba | 3 | WO |
| Medellin | 0 | |||
| 8-may-2022 | Tulua | Cortulua | 1 | Ruiz |
| Junior | 0 | |||
| 8-may-2022 | Envigado | Envigado | 1 | Hernandez (P) |
| Aguilas Doradas | 0 | |||
| 8-may-2022 | Bogota | Millonarios | 0 | |
| Tolima | 0 | |||
| 8-may-2022 | Barrancabermeja | Alianza Petrolera | 2 | Gil, Manjarres |
| Once Caldas | 0 | |||
| 20º Fecha | ||||
| 14-may-2022 | Bogota | Millonarios | 1 | Sosa |
| Alianza Petrolera | 0 | |||
| 14-may-2022 | Manizales | Once Caldas | 2 | Torijano, Perez |
| Santa Fe | 2 | Morelo (2) | ||
| 14-may-2022 | Pereira | Pereira | 0 | |
| Bucaramanga | 3 | Moreno (2), Acosta | ||
| 14-may-2022 | Bogota | La Equidad | 1 | Chaverra |
| Nacional | 0 | |||
| 14-may-2022 | Barranquilla | Junior | 2 | Uribe, Giraldo |
| Jaguares de Cordoba | 4 | Rojas (2, 1P), Arroyo, Rodriguez | ||
| 14-may-2022 | Medellin | Medellin | 1 | Pons |
| Pasto | 0 | |||
| 14-may-2022 | Rionegro | Aguilas Doradas | 2 | Marrugo, Puerta |
| Cortulua | 2 | Murillo, Ruiz | ||
| 14-may-2022 | Ibague | Tolima | 1 | Plata |
| Envigado | 1 | Hernandez (P) | ||
| 15-may-2022 | Tunja | Patriotas | 3 | Barrios (2), Lopez (P) |
| Cali | 0 | |||
| 15-may-2022 | Cali | America | 1 | Sierra |
| Union Magdalena | 0 | |||
| 1ª Fase | ||||
| Grupo A | ||||
| 1º Fecha | ||||
| 21-may-2022 | Barranquilla | Junior | 1 | Borja |
| Nacional | 1 | Moreno | ||
| 22-may-2022 | Bogota | Millonarios | 1 | Herazo (P) |
| Bucaramanga | 0 | |||
| 2º Fecha | ||||
| 31-may-2022 | Bucaramanga | Bucaramanga | 2 | Moreno, Mena |
| Junior | 0 | |||
| 31-may-2022 | Medellin | Nacional | 2 | Barrera, Guzman |
| Millonarios | 2 | Candelo (A), Ruiz | ||
| 3º Fecha | ||||
| 4-jun-2022 | Medellin | Nacional | 4 | Duque (2), Pabon, Guzman |
| Bucaramanga | 1 | Moreno | ||
| 4-jun-2022 | Barranquilla | Junior | 2 | Gonzalez, C. Valencia |
| Millonarios | 1 | J. Valencia | ||
| 4º Fecha | ||||
| 8-jun-2022 | Bogota | Millonarios | 0 | |
| Junior | 0 | |||
| 8-jun-2022 | Bucaramanga | Bucaramanga | 0 | |
| Nacional | 1 | Pabon (P) | ||
| 5º Fecha | ||||
| 11-jun-2022 | Barranquilla | Junior | 1 | Borja |
| Bucaramanga | 0 | |||
| 11-jun-2022 | Bogota | Millonarios | 0 | |
| Nacional | 0 | |||
| 6º Fecha | ||||
| 15-jun-2022 | Bucaramanga | Bucaramanga | 2 | Cardenas, Moreno |
| Millonarios | 1 | Gomez | ||
| 15-jun-2022 | Medellin | Nacional | 2 | Duque (2) |
| Junior | 1 | Hinestroza | ||
| Grupo B | ||||
| 1º Fecha | ||||
| 21-may-2022 | Envigado | Envigado | 1 | Baez |
| Tolima | 4 | Caicedo, Melendez, Orozco, Ibarguen | ||
| 21-may-2022 | Medellin | Medellin | 2 | Hernandez (2) |
| La Equidad | 0 | |||
| 2º Fecha | ||||
| 1-jun-2022 | Bogota | La Equidad | 2 | Camacho, Chaverra |
| Envigado | 0 | |||
| 1-jun-2022 | Ibague | Tolima | 0 | |
| Medellin | 0 | |||
| 3º Fecha | ||||
| 5-jun-2022 | Envigado | Envigado | 0 | |
| Medellin | 0 | |||
| 5-jun-2022 | Ibague | Tolima | 1 | Lucumi |
| La Equidad | 0 | |||
| 4º Fecha | ||||
| 9-jun-2022 | Bogota | La Equidad | 1 | Sabbag |
| Tolima | 0 | |||
| 9-jun-2022 | Medellin | Medellin | 2 | Cadavid (2, 1P) |
| Envigado | 1 | Ordoñez | ||
| 5º Fecha | ||||
| 12-jun-2022 | Envigado | Envigado | 0 | |
| La Equidad | 3 | Sabbag (P), Chaverra, Lima (P) | ||
| 12-jun-2022 | Medellin | Medellin | 0 | |
| Tolima | 1 | Plata | ||
| 6º Fecha | ||||
| 16-jun-2022 | Ibague | Tolima | 1 | Mosquera |
| Envigado | 0 | |||
| 16-jun-2022 | Bogota | La Equidad | 1 | Sabbag (P) |
| Medellin | 5 | Arregui (2, 1P), Mosquera (2), Pardo | ||
| FINAL | ||||
| 22-jun-2022 | Medellin | Nacional | 3 | Banguero, Candelo, Andrade |
| Tolima | 1 | Plata | ||
| 26-jun-2022 | Ibague | Tolima | 2 | Olivera (A), Caicedo |
| Nacional | 1 | Barrera | ||